PATH G6003 / G6004 Mechanisms of Human Disease
4.5 credits. Fall and spring semesters
Course Director: Dr. Ronald Liem

This course will provide an in-depth analysis of several organ systems and a disease associated with each organ system. The course will have four modules; each module will describe the basic physiology, nutritional status, health and anatomy of the organ system, the genetics, cell and biochemical mechanisms and pathologies associated with the disease, as well as basic pharmacology and therapeutics to treat the disease.


First Semester:

Module 1:
Hematopoetic System: Sickle Cell disease
Section Director: Yvette Thanheco

Module 2:
Nervous System: Alzheimer's Disease
Section Directors: Ron Liem

Module 3:
Cardiac System: Atherosclerosis
Section Director: Alan Tall

Second Semester:

Module 1:
Neuromuscular diseases
Section Directors: Ron Liem

Module 2:
Liver, Hepatitis and Cirrhosis
Section Director: Howard Worman

Module 3:
Multisystem Disorder: Diabetes
Section Directors: Anthony Ferrante

PATH G4500 Cellular & Molecular Biology of Cancer
3.0 credits. Fall semester
Course Directors: Benjamin Tycko and Richard Baer

This graduate level course provides a broad, but intensive, overview of basic cancer research.

Location: Irving Cancer Research Center, Room 114, First Floor (1130 St. Nicholas)
Time: 5:00 - 6:30 PM on selected M & W, as below

DateDayLecturerEmail addressTopics
9/8WB. Course overview: course structure and readings
9/13MB. Course overview: concepts in cancer biology
9/20MH. Hibshooshhhh1@columbia.eduTumor pathology
9/27MV. Murtyvvm2@columbia.eduTumor cytogenetics
9/29WT. Diacovotd2142@columbia.eduTumor invasion and metastasis
10/4MJ. Kitajewskijkk9@columbia.eduTumor angiogenesis
10/6WS. Goffgoff@cancercenter.columbia.eduViral carcinogenesis
10/11MR. Baerrb670@columbia.eduDominant oncogenes, I
10/13WR. Baerrb670@columbia.eduDominant oncogenes, II
10/18MT. Ludwigtl54@columbia.eduMouse models and the genetics of cancer
10/20WS. Zhasz2296@columbia.eduDNA repair and checkpoints
10/25MC. Troycmt2@columbia.eduApoptosis and cancer
10/27WMidterm ExamPick up from classroom Midterm Exam due one week after this date: 11/3
11/3WB. Tyckobt12@columbia.eduTumor suppressor genes and pathways, I
11/8MR. Parsonsrep15@columbia.eduTumor suppressor genes and pathways, II
11/10WW. Guwg8@columbia.eduThe p53 tumor suppressor
11/15MA. Iavaroneai2102@columbia.eduCell cycle: RB and related proteins
11/17WC. Abate-Shencabateshen@columbia.eduMouse models of prostate cancer
11/22-24M WThanksgiving WeekNo class
11/29ML. Pasqualuccilp171@columbia.eduLymphoma as a cancer model
12/1WA. Ferrandoas2196@columbia.eduMolecular genetics of leukemia
12/6MG. Sugs2157@columbia.eduPancreatic carcinoma as a cancer model
12/13ME. Gelmanngelmanne@columbia.eduTargeted therapies in human cancer
12/15WFinal ExamPick up from classroomFinal Exam due one week after this date: 12/22



PATH G4001 Cellular Tissue and Architecture
3.0 credits. Spring semester
Instructors: Ann-Judith Silverman and Ron Liem

Prerequisites: The course is limited to 2nd or 3rd year graduate students who have completed the core graduate courses, including "Biochemistry, Cell and Molecular Biology II" and "Mechanism of Human Disease."
Enrollment is limited, permission from instructor is required (Ron Liem,

Schedule: Sessions will be held on Thursdays from 10:00 AM - Noon.

Required Textbook: Junqueira and Carneiro Basic Histology (11th edition).

This course will focus on the practical aspects of using a microscope and of applying histological procedures to recognize cell types and tissue/organ organization.

The aim is to assist students in acquiring basic knowledge for analyzing tissues & organs and diseases related to these tissues & organs for application in their graduate research.

Each session will consist of didactic/lecture, microscope work and/or analysis of unknown samples. Student discussion and participation is necessary and assigned reading has to be done prior to class.

Assignments must be read before class
Lecture schedule:

  • Jan 27: Microscopic Techniques - Liza Pon
  • Feb 3: Stains and what they tell you - Ann-Judith Silverman
  • Feb 10: Kidney - Leal Herlitz and Glen Markowitz
  • Feb 17: Muscle and Muscle Pathologies - Arthur Hays and Liza Pon
  • Feb 24: Cartilage and Bone - Patricia Ducy
  • Mar 3: Liver - Jay Lefkowitz
  • Mar 10: Neuronal Stem Cells - Fiona Doetsch
  • Mar 17: No Class - Spring Break
  • Mar 24: Brain - Jim Goldman
  • Mar 31: Heart and Vasculature
  • Apr 7: Skin - Srikala Raghavan
  • Apr 21: No Class
  • Apr 28: Endocrine Glands - Ann Judith Silverman
  • May 5: Digestive System / GI System: Roger Moreira
  • May 12: Breast - Hanina Hibshoosh