Courses

PATH G6003 / G6004 Mechanisms of Human Disease
4.5 credits. Fall and spring semesters
Course Director: Dr. Ronald Liem

This course will provide an in-depth analysis of several organ systems and a disease associated with each organ system. The course will have four modules; each module will describe the basic physiology, nutritional status, health and anatomy of the organ system, the genetics, cell and biochemical mechanisms and pathologies associated with the disease, as well as basic pharmacology and therapeutics to treat the disease.

Schedule:

First Semester:

Module 1:
Hematopoetic System: Sickle Cell disease
Section Director: Yvette Thanheco

Module 2:
Nervous System: Alzheimer's Disease
Section Directors: Ron Liem

Module 3:
Cardiac System: Atherosclerosis
Section Director: Alan Tall

Second Semester:

Module 1:
Neuromuscular diseases
Section Directors: Ron Liem

Module 2:
Liver, Hepatitis and Cirrhosis
Section Director: Howard Worman

Module 3:
Multisystem Disorder: Diabetes
Section Directors: Anthony Ferrante

PATH G4500 Cellular & Molecular Biology of Cancer
3.0 credits. Fall semester
Course Directors: Benjamin Tycko and Richard Baer

This graduate level course provides a broad, but intensive, overview of basic cancer research.

Location: Irving Cancer Research Center, Room 114, First Floor (1130 St. Nicholas)
Time: 5:00 - 6:30 PM on selected M & W, as below

Date	Day	Lecturer	Email address	Topics
9/8	W	B. Tycko	bt12@columbia.edu	Course overview: course structure and readings
9/13	M	B. Tycko	bt12@columbia.edu	Course overview: concepts in cancer biology
9/20	M	H. Hibshoosh	hhh1@columbia.edu	Tumor pathology
9/27	M	V. Murty	vvm2@columbia.edu	Tumor cytogenetics
9/29	W	T. Diacovo	td2142@columbia.edu	Tumor invasion and metastasis
10/4	M	J. Kitajewski	jkk9@columbia.edu	Tumor angiogenesis
10/6	W	S. Goff	goff@cancercenter.columbia.edu	Viral carcinogenesis
10/11	M	R. Baer	rb670@columbia.edu	Dominant oncogenes, I
10/13	W	R. Baer	rb670@columbia.edu	Dominant oncogenes, II
10/18	M	T. Ludwig	tl54@columbia.edu	Mouse models and the genetics of cancer
10/20	W	S. Zha	sz2296@columbia.edu	DNA repair and checkpoints
10/25	M	C. Troy	cmt2@columbia.edu	Apoptosis and cancer
10/27	W	Midterm Exam	Pick up from classroom	Midterm Exam due one week after this date: 11/3
11/3	W	B. Tycko	bt12@columbia.edu	Tumor suppressor genes and pathways, I
11/8	M	R. Parsons	rep15@columbia.edu	Tumor suppressor genes and pathways, II
11/10	W	W. Gu	wg8@columbia.edu	The p53 tumor suppressor
11/15	M	A. Iavarone	ai2102@columbia.edu	Cell cycle: RB and related proteins
11/17	W	C. Abate-Shen	cabateshen@columbia.edu	Mouse models of prostate cancer
11/22-24	M W	Thanksgiving Week	No class
11/29	M	L. Pasqualucci	lp171@columbia.edu	Lymphoma as a cancer model
12/1	W	A. Ferrando	as2196@columbia.edu	Molecular genetics of leukemia
12/6	M	G. Su	gs2157@columbia.edu	Pancreatic carcinoma as a cancer model
12/13	M	E. Gelmann	gelmanne@columbia.edu	Targeted therapies in human cancer
12/15	W	Final Exam	Pick up from classroom	Final Exam due one week after this date: 12/22

PATH G4001 Cellular Tissue and Architecture
3.0 credits. Spring semester
Instructors: Ann-Judith Silverman and Ron Liem

Prerequisites: The course is limited to 2nd or 3rd year graduate students who have completed the core graduate courses, including "Biochemistry, Cell and Molecular Biology II" and "Mechanism of Human Disease."
Enrollment is limited, permission from instructor is required (Ron Liem, rkl2@columbia.edu).

Schedule: Sessions will be held on Thursdays from 10:00 AM - Noon.

Required Textbook: Junqueira and Carneiro Basic Histology (11th edition).

This course will focus on the practical aspects of using a microscope and of applying histological procedures to recognize cell types and tissue/organ organization.

The aim is to assist students in acquiring basic knowledge for analyzing tissues & organs and diseases related to these tissues & organs for application in their graduate research.

Each session will consist of didactic/lecture, microscope work and/or analysis of unknown samples. Student discussion and participation is necessary and assigned reading has to be done prior to class.

Assignments must be read before class
Lecture schedule:

Jan 27: Microscopic Techniques - Liza Pon
Feb 3: Stains and what they tell you - Ann-Judith Silverman
Feb 10: Kidney - Leal Herlitz and Glen Markowitz
Feb 17: Muscle and Muscle Pathologies - Arthur Hays and Liza Pon
Feb 24: Cartilage and Bone - Patricia Ducy
Mar 3: Liver - Jay Lefkowitz
Mar 10: Neuronal Stem Cells - Fiona Doetsch
Mar 17: No Class - Spring Break
Mar 24: Brain - Jim Goldman
Mar 31: Heart and Vasculature
Apr 7: Skin - Srikala Raghavan
Apr 21: No Class
Apr 28: Endocrine Glands - Ann Judith Silverman
May 5: Digestive System / GI System: Roger Moreira
May 12: Breast - Hanina Hibshoosh